SH-SY5Y neuroblastoma

By Targets:	Amyloid-β (1) Apoptosis (2) Autophagy (2) Cholinesterase (ChE) (2) Deubiquitinase (1) ERK (1) HSP (1) Huntingtin (1) Keap1-Nrf2 (1) mGluR (1) Mitochondrial Metabolism (1) Monoamine Oxidase (3) NAMPT (1) NF-κB (1) Opioid Receptor (1) PKC (1) RAR/RXR (1) Reactive Oxygen Species (2) Sirtuin (1) α-synuclein (1) γ-secretase (2)
By Research Areas:	Cancer (7) Infection (1) Inflammation/Immunology (3) Neurological Disease (11)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14374

GPP78 1 Publications Verification CAY10618	NAMPT Autophagy	Inflammation/Immunology Cancer
GPP78 (CAY10618) is a potent Nampt inhibitor with an IC₅₀ of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC₅₀ of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects .

HY-N0303

Idebenone 3 Publications Verification	Mitochondrial Metabolism Apoptosis	Neurological Disease
Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC₅₀=16.65 μM) . Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells . Idebenone quickly crosses the blood-brain barrier.

HY-117482

BPN-15606	γ-secretase	Neurological Disease
BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC₅₀ values of 7 nM and 17nM, respectively. BPN-15606 lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 has acceptable PK/PD properties, including bioavailability, half-life, and clearance .

HY-161156

BChE-IN-26	Cholinesterase (ChE)	Neurological Disease Cancer
BChE-IN-26 (Compound 7b) is a selective AChE and BChE inhibitor with K_i value of 35 μM and 1.6 μM. BChE-IN-26 has cytotoxicity to human neuroblastoma (SH-SY5Y) cell line. BChE-IN-26 can be used for the research of Alzheimer’s disease .

HY-117482A

BPN-15606 besylate	γ-secretase	Neurological Disease
BPN-15606 besylate is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC₅₀ values of 7 nM and 17nM, respectively. BPN-15606 besylate lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 besylate has acceptable PK/PD properties, including bioavailability, half-life, and clearance .

HY-149477

IHC3	Monoamine Oxidase	Neurological Disease
IHC3 is a competitive and reversible MAO-B inhibitor (IC₅₀: 1.672 μM). IHC3 can interact with the amino acid Cys172 of MAO-B. IHC3 can be used for neurological diseases research .

HY-134476

NF-κΒ activator 1 3 Publications Verification	NF-κB	Inflammation/Immunology
NF-κΒ activator 1 is a potent NF-κΒ activator with an EC₅₀ of 0.9 μM. NF-κΒ activator 1 induces superoxide dismutase (SOD)2 mRNA expression .

HY-P3087

Tyr-W-MIF-1

Opioid Receptor Neurological Disease

Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia .
HY-N8418

Cearoin

Autophagy Reactive Oxygen Species ERK Apoptosis Cancer

Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK .

Tyr-W-MIF-1	Opioid Receptor	Neurological Disease
Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia .

Cearoin	Autophagy Reactive Oxygen Species ERK Apoptosis	Cancer
Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK .

HY-14649G

Retinoic acid Vitamin A acid; all-trans-Retinoic acid; ATRA	RAR/RXR	Cancer
Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors .

HY-16009

Buntanetap (+)-Phenserine; ANVS401	Cholinesterase (ChE) Amyloid-β α-synuclein Huntingtin	Neurological Disease Inflammation/Immunology
Buntanetap ((+)-Phenserine) is a multiple neurotoxic protein translation inhibitor with oral activity, including amyloid precursor protein (APP), α-synuclein (αSYN) and huntingtin protein (HTT). Buntanetap has anti-inflammatory effects and can be used in the study of Alzheimer's disease and Parkinson's disease .

HY-15141G

Staurosporine Antibiotic AM-2282; STS; AM-2282	PKC	Infection Cancer
Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases .

HY-162050

8AQ−Cu−5Iu	Sirtuin	Neurological Disease
8AQ?Cu?5Iu is an activator of SIRT1. 8AQ?Cu?5Iu exhibits neuroprotective effects by modulating the SIRT1/3-FOXO3a signaling pathway. 8AQ?Cu?5Iu can used in study attenuating neurodegenerative diseases .

HY-144635

Nrf2-ARE/hMAO-B/QR2 modulator 1	Monoamine Oxidase Keap1-Nrf2 Reactive Oxygen Species	Neurological Disease
Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands with IC₅₀s of 8.05, 9.83 and 0.57 μM for hMAO-B, NRF2 and QR2. Nrf2-ARE/hMAO-B/QR2 modulator 1 has neuroprotection, decreasing ROS production in okadaic acid-treated mice hippocampal slices .

HY-136910

USP7-IN-7	Deubiquitinase	Cancer
USP7-IN-7 (compound 124) is a USP7 inhibitor with an IC₅₀ value ＜10 nM. USP7-IN-7 shows cytotoxicity against p53-mutant cancer cell lines, p53 wild-type blood cancer and neuroblastoma cell lines with low nanomolar values. USP7-IN-7 can be used for cancer research .

HY-149234

MAO-B-IN-18	Monoamine Oxidase	Neurological Disease
MAO-B-IN-18 is a potent and selective MAO B inhibitor with IC₅₀s of 52 nM and 14 μM for hMAO B and hMAO A, respectively. MAO-B-IN-18 enables promising cytoprotective effects against hydrogen peroxide insults in neuroblastoma and astrocytes cultures .

HY-110122

AZ 12216052 1 Publications Verification	mGluR	Neurological Disease
AZ 12216052 is a mGluR8 positive allosteric modulator, and helps mGluR8 modulate signaling inputing to retinal ganglion cells. AZ 12216052 exhibits antianxiety effect .

HY-151335

KU-177	HSP	Cancer
KU-177 is a potent inhibitor of Hsp90 ATPase homologue 1 (Aha1), ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation. KU-177 also disrupts Aha1/Hsp90 interactions (IC₅₀=4.08 μM) without inhibition of Hsp90’s ATPase activity. KU-177 can be used for tauopathies research .

Cat. No.	Product Name	Type

HY-14649G

Retinoic acid (GMP) Vitamin A acid (GMP); all-trans-Retinoic acid (GMP); ATRA (GMP)	Fluorescent Dye
Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors .

HY-15141G

Staurosporine (GMP) Antibiotic AM-2282 (GMP); STS (GMP); AM-2282 (GMP)	Fluorescent Dye
Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases .

Cat. No.	Product Name	Type

HY-14649G

Retinoic acid (GMP) Vitamin A acid (GMP); all-trans-Retinoic acid (GMP); ATRA (GMP)	Biochemical Assay Reagents
Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors .

HY-15141G

Staurosporine (GMP) Antibiotic AM-2282 (GMP); STS (GMP); AM-2282 (GMP)	Biochemical Assay Reagents
Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases .

Cat. No.	Product Name	Target	Research Area

HY-P3087

Tyr-W-MIF-1

Opioid Receptor Neurological Disease

Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia .

Tyr-W-MIF-1	Opioid Receptor	Neurological Disease
Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8418

Cearoin	Dalbergia odorifera T. Chen Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Autophagy Reactive Oxygen Species ERK Apoptosis
Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK .

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SH-SY5Y neuroblastoma

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